1. Sodium Ascorbyl Phosphate Overview

Where to buy Sodium Ascorbyl Phosphate (SAP) Powder with lowering Sodium Ascorbyl Phosphate (SAP) price and high quality? Where to find good information of Wholesale Sodium Ascorbyl Phosphate (SAP) and Purchase Sodium Ascorbyl Phosphate (SAP) for sales? As the professional Sodium Ascorbyl Phosphate (SAP) manufacturer, BFSTAR is your best choice.

Sodium Ascorbyl Phosphate (SAP) is a stable vitamin C derivative. It is processed from vitamin C as a raw material. After entering human body, it rapidly transforms into VC through enzymolysis. Thereby, SAP plays its unique physiological and biochemical functions. Sodium Ascorbyl Phosphate is white or pale yellow powder. It is soluble in water, propylene glycol and glycerin; but it’s almost insoluble in ethanol.

Sodium Ascorbyl Phosphate factory

Sodium Ascorbyl Phosphate is a water-soluble cosmetic whitening additive. After transdermal absorption, it can effectively resist ultraviolet damage, and capture free radicals. Also it can promote collagen production. It has anti-oxidation and anti-aging effect. Moreover, SAP can effectively prevent pigmentation; it helps to eliminate skin spots, such as freckles and age spots. In addition, Sodium Ascorbyl Phosphate has a therapeutic effect on facial acne and pimple.

Product Name CAS Number INCI Name
Sodium Ascorbyl Phosphate 66170-10-3 SODIUM ASCORBYL PHOSPHATE
Molecular Weight Molecular Formula Molecular Structure
322.05g/mol C6H6Na3O9P
Product ID Specificcation Minimal Package Minimal Order Quantity
BFSTAR2103 98% 1KG 1KG

2. Sodium Ascorbyl Phosphate Source

Currently, there are two methods for the synthesis of Sodium Ascorbyl Phosphate: chemical synthesis (group protection method and direct acylation method) and microbial synthesis (biological fermentation method).

Direct acylation Group protection
Process Vitamin C and sodium hydroxide solution are esterified under the action of enzyme produced by microorganisms. And then post-treated to obtain Sodium Ascorbyl Phosphate. Vitamin C is acylated in pyridine and water system. The protecting group is removed under acidic conditions. And then neutralize with alkali to obtain Sodium Ascorbyl Phosphate.
Advantage Less by-products; less pollution to environment. /
Disadvantage / Complex reaction process. After the reaction, there are many residual by-products that are difficult to remove.

3. Sodium Ascorbyl Phosphate Manufacturer Specifications

Product Name Specification
Sodium Ascorbyl Phosphate 98%

 

Items Specification
Appearance White or pale yellowish powder
Assay ≥98%
Identification IR(Infrared Ray)
Physical Characteristics
Vitamin C content ≥45%
Loss on drying ≤11.0%
pH (3% aqueous solution) 8.00–11.0
Heavy Metals
Heavy Metals ≤20ppm
As ≤2ppm

4. Sodium Ascorbyl Phosphate Manufacturer Flow Chart

5. Sodium Ascorbyl Phosphate Benefits

  • Anti-aging

Sodium Ascorbyl Phosphate is an effective oxygen free radical scavenger. It protects skin from UV rays, and enhances photo-protective property of sunscreens. Moreover, it is more effective in combination with vitamin E or vitamin E derivatives. Also SAP has some improvement on facial wrinkles and fine lines.

SAP refers to Sodium Ascorbyl Phosphate; VEA refers to Vitamin E acetate.

  • Whitening skin

Experiments have shown that 2% Sodium Ascorbyl Phosphate in cosmetics can significantly reduce pigmentation, and whiten skin. It has no irritating effect on skin. This is because SAP is absorbed by skin and then hydrolyzed to vitamin C. Thereby it can decrease melanin formation, and inhibit pigmentation. Then SAP can exert effect of whitening skin and removing freckle.

  • Acne treatment

In an in vitro study, a moderate concentration of 1% sodium ascorbyl phosphate shows a strong antibacterial effect on acne. In addition, in a study of 76.9% of patients with facial acne, the use of 5% sodium ascorbyl phosphate is significantly better than other acne treatments after 12 weeks. It has no side effects. In addition, other clinical studies have shown that SAP is more effective in treating acne than 5% benzoyl peroxide, 1% phosphate clindamycin, and 0.1% adapalene.

6. Sodium Ascorbyl Phosphate Advantages

1. Compared with vitamin C

Vitamin C is a catalyst in cell oxidation-reduction reaction. Human body cannot synthesize itself. Vitamin C must be taken from food. High activity is the advantage of vitamin C, but at the same time it is the inadequacy, mainly as follows: (1) unstable, susceptible to light, heat, etc. The reduction ability of vitamin C will be lost after decomposition. Expose vitamin C at room temperature for one day, the loss is more than 50%; and it decomposes faster under high temperature or light. (2) It is easily dehydrated and loses its activity in an acidic medium at high temperature.

The activity of vitamin C is mainly derived from two hydroxyl groups on its enol structure. If any of its hydroxyl groups are esterified with mineral acid, the stability to heat, acid and oxygen will greatly enhance. For example, the antioxidant capacity of phosphate derivatives of vitamin C in boiling water is about 10 times that of vitamin C. Compared with vitamin C, Sodium Ascorbyl Phosphate (1) is chemically stable and difficult to be oxidized; (2) has high thermal stability; (3) has high bioavailability, and can also be decomposed by phosphatase in human body. It has same effects as vitamin C.

2. Comparison with other vitamin C derivatives

Common vitamin C derivatives include vitamin C metal salts, vitamin C phosphates, vitamin C sulfates, and vitamin C palmitate.

Although vitamin C metal salt is simple and easy to obtain, it is not stable due to easy moisture absorption. Studies have found that vitamin C sulfate cannot be absorbed by body. The palmitate resources required for vitamin C palmitate are not abundant, and it is not suitable for large-scale production. The shortcomings of vitamin C phosphate magnesium in industrial production and application are mainly as follows: the crystallization yield is low; and it is difficult to separate from by-products produced by the reaction; the dissolution rate in water is very low; and it is easy to change color after being placed.

Sodium Ascorbyl Phosphate overcomes the shortcomings of the above vitamin C derivatives. It has high stability and good water solubility. It can be decomposed and utilized by phosphatase in human body. Also it is suitable for large-scale production.

7. Sodium Ascorbyl Phosphate Application and Reference Dosage

As a common whitening additive, Sodium Ascorbyl Phosphate is widely used in various functional cosmetics, such as whitening cream, lotion, facial cleanser, toner, and other anti-wrinkle skin care products.

Application Reference Dosage
Daily skin-care 0.2-2%
Sunscreen 0.2-1%
Skin-whitening 3-5%
Treatment of acne 5%

Note:

  • Water-soluble Sodium Ascorbyl Phosphate and oil-soluble vitamin E acetate have synergistic effect. The combination of the two forms an excellent anti-oxidation system.
  • Compounding with ascorbyl palmitate also enhances SAP’s anti-oxidation property.
  • In a cosmetics formulation, Sodium Ascorbyl Phosphate should be added when temperature is less than 40°C.
  • Sodium Ascorbyl Phosphate is most stable above pH 6.5, and will change color when pH is lower than 6.
  • Cosmetics containing Sodium Ascorbyl Phosphate should be stored below 25°C.

Sodium Ascorbyl Phosphate application cases in major cosmetic brands in the world

Country Brand Product
USA Elizabeth Arden Visible Whitening Melanin Control Night Capsules with Advanced MIX ConcentrateTM
SUNPLAY Skin Aqua UV Super Moisture Gel
Radha Beauty Vitamin C Serum
Paula‘s Choice Resist Anti-Aging Clear Skin Hydrator

Skin Revealing Body Lotion with 10% AHA

Olay Total Effect 7 in One Moisturizing Vitamin Treatment

Natural White Pinkish Whtening Cream

SPF30+/PA+++ Pro-X White Anti-yellow Repair Cream SPF30+/PA+++

Australia Swisse Argan Anti-Ageing Eye Cream
Freeze Frame Eye Solution
Aesop Parsley Seed Anti-Oxidant Eye Cream
China Herborist Whitening & Revitalizing Lotion
Franic Rose Buds Tone-Up Cream
UNIFON Radiant Golden Osmanthus Eye Mask
Korea MEDIHEAL Tea-tree Healing Solution Essential Mask

Collagen Impact Essential Mask

Dr. Jart V7 Toning Light
SULWHASOO) Time-treasure Renovating Serum Ex

Time-treasure Renovating Eye Cream

Germany AnneMarie Borlind Orange Blossom Energizer

Rose Blossom Revitalizing Care

Eucerin Aquaphor Lip Repair Immediate Relief
UK Dr Sebagh Pure Vitamin C Powder Cream
Japan HABA VC Lotion

White Lady

8. Sodium Ascorbyl Phosphate Reference Formula

  • Whitening mask
Ingredient Content (%) Ingredient Content (%)
Sodium Ascorbyl Phosphate 2 Rhodiola root extract 0.4
Butanediol 4.25 Diazolidinyl urea 0.42
Glycerin 6 Propylene glycol 5
PEG-60 hydrogenated castor oil 0.3 Hydroxyethyl cellulose 0.3
Disodium EDTA 0.1 Fragrance 0.1
Water 81.13

Preparation method

  1. Add 76.8% water and disodium EDTA to the stirring pot. Heat to 85°C while stirring, so that disodium EDTA is fully integrated into water, and then keep for 10 minutes.
  2. Add glycerin, propylene glycol, 4% butanediol, 0.4% diazolidinyl urea, hydroxyethyl cellulose to stirring pot and stir until completely dispersed.
  3. Cool down to 40°C, add 4.33% water, rhodiola root extract, 0.25% butanediol, 0.02% diazolidinyl urea, Sodium Ascorbyl Phosphate into stirring pot; stir evenly.
  4. Add PEG-60 hydrogenated castor oil and fragrance to stirring pot. Stir evenly, and then cool down to 15°C to obtain the mask.
  • Nourishing facial mask fluid
Ingredient Content (%) Ingredient Content (%)
Sodium Ascorbyl Phosphate 1 Allantoin 0.1
Xanthan gum 0.15 Glycerin 4
Butanediol 3 Sodium hyaluronate 0.03
Hydroxyethyl urea 1 Sorbitol 1
Bearberry leaf powder 2 Cucumis Sativus Fruit Extract 0.2
Grapefruit peel extract 0.5 Pomegranate peel extract 0.1
Iodopropynyl butylcarbamate 0.2 Diazolidinyl urea 0.2
Fragrance 0.3 Deionized water 86.22
  • Whitening emulsion
Phase Ingredient Content (%) Ingredient Content (%)
Phase A Sodium Ascorbyl Phosphate 0.3 Xanthan gum 0.3
1,2-Propylene glycol 9.73 Sorbitol 2.22
Diglycerol 0.33 Methyl gluceth-20 1.73
Water 72.91 Aminopropanol ascorbic acid phosphate 0.3
Ethylresorcinol 0.3 EDTMP·Na5 0.1
Pentasodium pentetate 0.1 Citric acid 0.05
Sodium hydroxide 0.023 Methylparaben 0.2
Phenoxyethanol 0.6
Phase B PEG-100 stearate 1.5 Inulin Lauryl Carbamate 0.4
Mineral oil 3.0 Olive oil 1.0
Octanoglycerate 2.0 Glyceryl stearate 0.7
Polydimethylsiloxane 1.74 Propylparaben 0.08
Phase C Leontopodium alpinum flower/leaf extract 0.1 Ginseng root extract 0.1
Fragrance 0.127 1% Xanthein CI15985 0.06

Preparation method

  1. Mix the raw materials of phase A and heat to 85°C; stir evenly, and keep at 85°C for use.
  2. Mix the raw materials of phase B and heat to 85°C; stir evenly, and keep at 85°C for use.
  3. Mix the materials obtained in the above steps 1 and 2. Use a homogenizer; keep at 83-85°C and homogenize at 2800 rpm for 15 minutes, and then cool to 38°C.
  4. Add the raw materials of phase C and mix well to obtain the whitening emulsion.

Note: The formulation’s water activity is 0.87; pH is 4.3; and viscosity is 7500cps at room temperature.

  • Sunscreen lotion
Phase Ingredient Content (%) Ingredient Content (%)
Phase A Cremophor W07 6 Cremophor RH40 0.5
Isopropyl palmitate 7 Elfacos ST9 2.0
Jojoba oil 3.0 Magnesium stearate 0.6
Uvinul MC80 8.0 Finsolv TN 5.0
Kemira 160 4.0
Phase B Propylene glycol 5.0 Disodium EDTA 0.2
Preservative Appropriate Deionized water 57.20
Phase C Vitamin E acetate 0.5 Sodium Ascorbyl Phosphate 1.0

Preparation method

Heat phase A and phase B raw separately to 80°C, and then put phase A into phase B and homogenize. Then add phase C materials and homogenize to obtain the sunscreen lotion.

  • Body lotion
Phase Ingredient Content (%) Ingredient Content (%)
Phase A Cremophor RH40 1.5 Fragrance Appropriate
Phase B Propylene glycol 3.0 Bisabolol 0.1
Ethanol 15.0 Witch hazel distillate 2.0
Water 78.2 Sodium Ascorbyl Phosphate 0.2

Preparation method

Dissolve phase A ingredients. Dissolve phase B and stir it into phase A.

Note: adjust pH value to 5-6.

  • Anti-wrinkle night cream
Phase Ingredient Content (%) Ingredient Content (%)
Phase A Cremophor W07 6 Paraffin 10.0
Vaseline 3.0 Miglyol 812 5.0
Elfacos ST9 2.0 Jojoba oil 5.0
Claytone XL 1.0
Phase B Propylene glycol 3.0 Disodium EDTA 0.1
Preservative Appropriate Water 63.4
Phase C Retinol 1.0 Sodium Ascorbyl Phosphate 0.5
Fragrance Appropriate    

Preparation method

Heat phases A and B ingredients separately to 85°C. Stir phase B into phase A and homogenize thoroughly. Cool to 40°C; then add phase C and homogenize again.

  • Whitening cleanser
Ingredient Content (%) Ingredient Content (%)
Sodium Ascorbyl Phosphate 1.0 Magnesium Ascorbyl Phosphate 1.0
Vitamin E sodium phosphate 1.0 Avocado oil 11.0
Behenyl alcohol 0.6 Stearic acid 0.4
Glycerin fatty acid ester 0.9 Sorbitan fatty acid ester 1.1
Polyoxyethylene alkyl ether 0.4 1,3- butanedio 10.1
Methyl benzoate 0.2 Fragrance 0.4
Water Add to 100

9. Sodium Ascorbyl Phosphate Safety

  • The CIR Expert Panel has experimentally concluded that sodium ascorbyl phosphate is safe for use in cosmetics;
  • According to Australian National Industrial Chemicals Notification and Assessment Scheme, the maximum concentration of sodium ascorbyl phosphate in most cosmetic formulations is 5%; and the maximum concentration in sunscreen products is 1%. Otherwise it causes side effect such as skin irritation.
  • Sodium Ascorbyl Phosphate has been included in The Catalog Of the International Cosmetics Raw Material Standard Chinese Name issued by Food and Drug Administration in 2010.

10. Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.