1. Nicotinamide & Niacinamide & Vitamin b3 Overview
Where to buy Nicotinamide & Niacinamide Powder with lowering Nicotinamide & Niacinamide price and high quality? Where to find good information of Wholesale Nicotinamide & Niacinamide and Purchase Nicotinamide & Niacinamide for sales? As the professional Nicotinamide & Niacinamide suppliers,BFSTAR is your best choice.
Nicotinamide & Niacinamide is a vitamin B form. It can be also called Vitamin B3. It is a significant niacin derivative, mainly occurring in many organisms. Nicotinamide & Niacinamide can produce coenzyme Ⅰ and Ⅱ when it reacts with ribose, adenine and phosphoric acid. Also it boosts the synthesis of DNA, fats and proteins and improves the energy metabolism of cells. So it can greatly prevent melanin deposition, and reduce discoloration. It has an effective whitening function. Nowadays, as a natural cosmetics ingredient, it is widely applied in skin and hair care products. BFSTAR Nicotinamide is divided into medical grade and cosmetics grade.
| Product Name | CAS Number | INCI Name | |
| Nicotinamide | 98-92-0 | NIACINAMIDE | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| C6H6N2 O | 112.1g/mol |
 |
|
| Product ID | Specificcation | Minimal Package | Minimal Order Quantity |
| BFSTAR140101 | 99% | 1KG | 1KG |
2. Nicotinamide & Niacinamide Preparation Method
Nicotinamide is obtained by synthesis. There are 2 methods: biosynthesis and chemical. BFSTAR produces Nicotinamide by the biological method, because of its non-pollution, low consumption and suitability for mass production. All of these advantages can benefit customers a lot.
| Methods | Merits | Demerits | |
| Biosynthesis | Firstly, use microbial catalyst to produce 3-cyanopyridine. Secondly, obtain Nicotinamide by hydrolyzing 3-cyanopyridine | Pollution-free, low material consumption, advanced technology, good product quality, suitability for mass production. | The method is a little complicated. But it can be improved with the development of science and technology. |
| Chemical | Obtain Nicotinamide by using 3-methylpyridine as catalyst. | The method is simple and easy to get catalyst. Only using one step to obtain Nicotinamide. | High raw material consumption, severe environmental pollution, instability of production quality, and small production scale. |
3. Nicotinamide & Niacinamide & Vitamin b3 Manufacturer Specifications
| Items | Specifications |
| Assay | ≥99.0% |
| Appearance | White crystalline powder |
| Physical Characteristic | |
| Melting point | 128.0℃-131.0℃ |
| Loss on Drying | ≤0.5% |
| Residue on ignition | ≤0.1% |
| Related substances | ≤0.5 |
| Readily carbonized substance | Conforms |
| Clarity and color of solution | Clear and colorless |
| Absorption coefficient | E1 cm 1%: 417-443 |
| pH | 5.5-7.5 (10% solution) |
| Heavy Metal | |
| Total Heavy Metals | ≤20ppm |
4. Nicotinamide & Niacinamide & Vitamin b3 Manufacturer Process Flow Chart
5. Niacinamide Benefits
- Prevent melanin from depositing into keratinocytes
Skin will darken when melanin is delivered to keratinocytes. But Nicotinamide can act on generated melanin, and then efficiently prevent the transfer of 35% to 40% of melanin from melanocytes to horny cells. Hence, it can lessen excessive pigmentation. Clinical tests have suggested that Nicotinamide face cream can obviously reduce the brown spots ‘ number and area.
- Accelerate the metabolism of melanocytes
Nicotinamide is directly absorbed by cells owing to its small molecules. Nicotinamide can penetrate the inner layer of the skin within 2 hours. Using Nicotinamide to the skin can form energy molecules in human body quickly. It can penetrate the stratum corneum to the connective tissue and fibers between the dermis; and then it directly gets in the bottom of the cell to facilitate the metabolism of cells.
- Promote synthesis of cortical proteins on skin
Nicotinamide synthesizes protein on the surface of skin. And it amends skin texture, and moisturizes skin. In 1990, European Patent 0-396-422 shows that it can whiten skin and exert sun block effect to add Nicotinamide, 0.1% to 5% silicone compound and UVA, UVB sunscreen into the cream formulation.
6. Application and Reference Dosage of Niacinamide
Nicotinamide is applied in skin-care products, such as whitening cream, spot removing essence, moisturizing lotion, etc. Also it can be added into shampoo, hair conditioner to stop hair loss and relieve itch. Usually it can be mingled with glycerol, retinol to make cosmetics.
| Specification | Reference Dosage |
| Nicotinamide 99% | 0.5%-2% |
Attention：
- When pH value of Nicotinamide is less than 5, it will be disintegrated to niacin. Niacin is harmful for skin. Therefore, Nicotinamide’s pH value should be controlled in range of 5~7.
- Nicotinamide can hardly absorbed by skin when above 5% concentration’s. Below 5% dosage will be beneficial to skin. Thus the dosage of Nicotinamide should be controlled.
- Avoid to use Niacinamide with salicylic acid, alpha hydroxy acid and other acids. Because under acidic conditions, Niacinamide will be decomposed into niacin, causing irritation.
Nicotinamide’s application cases in cosmetics around the world:
| Country | Brand | Product |
| Japan | SK-Ⅱ | Aura Essence |
| Korea | The Face Shop | Anti Aging Serum |
| France | Bioderma | Atoderm PP Balm |
| Cetaphil | Body Moisturizer | |
| USA | CeraVe |
Sunscreen Face Lotion, Foaming Facial Cleanser
Skin Renewing Night Cream, |
| Dermedicine | Natural Niacinamide Ultimate Strength Vitamin B Cream for Face | |
| InstaNatural | Niacinamide 5% Face Serum | |
| Body Merry | Breakthrough Night Cream | |
| Face n Earth, LLC | Oil-Free Cream | |
| Olay | Regenerist Regenerating Serum | |
| The Ordinary | Niacinamide 10% + Zinc 1% | |
| TruSkin Naturals |
Vitamin C-Plus Super Serum
Anti Aging Anti-Wrinkle Facial Serum |
|
| LuxaDerme |
Brightening Bio Cellulose Face Sheet Mask |
7. Niacinamide Reference Formula
Whitening toner：
| Ingredient | Content（%） | Ingredient | Content（%） |
| Niacinamide | 0.18 | Pantothenic acid | 0.25 |
| Vitamin E acetate | 0.8 | Pyridoxine hydrochloride | 0.1 |
| EDTA disodium | 0.08 | Prawn ridge orchid extract | 9.0 |
| Ethanol | 7.85 | Water | Add to 100 |
Shampoo：
| Ingredient | Content（%） | Ingredient | Content（%） |
| Niacinamide | 0.1 | Methylparaben | 0.20 |
| Naphtha | 3.50 | Hydroxypropyl methyl cellulose | 0.60 |
| Glucose monohydrate | 2.00 | Polyglycerol/methyl glucose-distearate | 0.40 |
| Mixed-alcohol | 4.80 | Deionized water | Add to 100 |
| Monostearin | 0.30 | Sovermol(r)760 | 0.25 |
| Dehyquart(r)F75 | 0.35 | Cetyl-trimethyl ammonium chloride | 3.00 |
| Propylparaben | 0.20 | D-panthenol | 0.25 |
8. Nicotinamide Safety
- Both European Union (EU) and Cosmetic, Toiletry and Fragrance Association(CTFA) have recognized Nicotinamide as cosmetics ingredient.
- CAFFCI’s 2010 edition-The Catalog Of the International Cosmetics Raw Material Standard English Name and On the Announcement of Name List of Cosmetics Raw Material published by China Food and Drug Administration(CFDA) in 2014 also specify Nicotinamide as cosmetics component.
9. Packing and Storage
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and heat.
